7/14/2023 0 Comments Aging zebrafish circuli![]() Depending on the duration of the exposure to stressful stimuli, stress can be considered acute or chronic. Stress responses are a crucial adaptation for proper resource allocation toward cognitive and muscular performance. Physiological balance can be temporarily disrupted by external conditions including stressors. Our results suggest there is a close relationship between chronic stress, regeneration, and behavior in zebrafish ( Danio rerio), and that the impact of stress is age-dependent. The expression of stress-related gene candidate sam2 increased in the brain of older individuals exposed to stress. We further investigated the expression of two candidate genes ( nlgn1 and sam2) expressed in the central nervous system, and known to be associated with stress and anxiety-like behavior. On the other hand, older fish regenerated their caudal fin significantly slower compared to young fish, but their behavior remained unaffected after being exposed to stress. Only young fish showed a significant change in anxiety-like behaviors after being exposed to chronic stress, while their regeneration ability was not affected by the stress protocol. We found evidence that young and older adult fish are differentially impacted by stress. Here, we subjected young and old zebrafish to a chronic stress protocol and evaluated the impact of stress exposure on multiple measures of zebrafish behavior, specifically thigmotaxis (open field test) and scototaxis (light/dark preference test), and on regeneration ability after partial tail amputation. ![]() However, the relationship between stress and regeneration, and how this relationship changes with age remains poorly understood. Stress can have a significant impact on many aspects of an organism’s physiology and behavior. ![]()
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